Recommended intravenous and oral dosing schedule 0 hours 2 hours 6 hours ifosfamide 1. Ifosfamide is also sometimes used to treat bladder cancer, lung cancer, cancer of the ovaries cancer that begins in the female reproductive organs where eggs are formed, cancer of the cervix, and certain types of soft tissue or bone sarcomas cancer that forms in muscles and bones. Voorma, ingevolge het besluit van het college voor promoties. The use of the information on this website does not create a physicianpatient relationship between cancer care ontario and you. Ifosfamide, carboplatin, and cisplatin can cause renal complications, including acute tubular dysfunction, although carboplatin is less nephrotoxic than cisplatin. Since the growth of normal body cells may also be affected by ifosfamide, other effects will also occur. Highlights of prescribing information these highlights. Deactivation of ifosfamide leads to the release of the potentially neurotoxic chloracetaldehyde kerbusch et al. Oct 18, 2019 mesna should be used to reduce the incidence of hemorrhagic cystitis.
Ixempra ixabepilone dosing and administration guide. The total daily dose of mesnex is 100% of the ifosfamide dose. Store intact vials at room temp or under refrigeration. Aug, 2018 ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. These highlights do not include all the information needed to. Ifosfamide intravenous route precautions mayo clinic.
Ifosfamide neurotoxicity and potential treatment with. Used as an antineoplastic agent in treatment of leukemia, lymphoma, and cancers of the lung, ovary, testes, and other organs. Doses and duration of treatment andor treatment intervals depend on the therapeutic indication, the scheme of a combination. Clinical pharmacology of ifosfamide and metabolites. Ifosfamide metabolites accumulation can produce neurotoxicity, which sometimes manifests as a severe clinical picture. Ifosfamide 2g powder for concentrate for solution for injection vials baxter healthcare ltd active ingredients size unit nhs indicative price drug tariff drug tariff price.
Aug, 2018 our ifex ifosfamide side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Ifex ifosfamide for injection prescribing information. Ifosfamide is 32chloroethyl22chloroethylaminotetrahydro2h1,3,2. Ifex ifosfamide for injection singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. The total daily dose of mesna is 100% of the ifosfamide dose. Highlights of prescribing information these highlights do not include all the information needed to use tecentriq safely and effectively. Ifosfamide is an alkylating agent used in the treatment of several neoplasias. Oct 24, 2016 ifosfamide is a cytotoxic drug for the treatment of malignant disease. The risk and expected benefits of ifosfamide therapy should be carefully weighed when considering the use of ifosfamide in patients with preexisting renal impairment or reduced nephron reserve. See how any two prescription or overthecounter medications stack up on dosage, side effects, interactions, and more. Mesnex is indicated as a prophylactic agent in reducing.
Ifosfamide ifo, sold under the brand name ifex among others, is a chemotherapy medication used to treat a number of types of cancer. This information is independently developed by mims based on ifosfamide from various references and is provided for your reference only. This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer. Myocardial damage can occur with doxorubicin hydrochloride with incidences from 1% 20% for cumulative doses from 300mgm2 to 500mgm2 when doxorubicin hydrochloride is administered every 3weeks. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage. This typically regresses after completing treatment. The use of the information on this website does not create a physician. The recommended dosing schedule is outlined in table 2. Although ifosfamide has been administered to a small number of patients with compromised hepatic andor renal function, studies to establish optimal dose schedules of ifosfamide in such patients have not been conducted. Ifosfamide definition of ifosfamide by medical dictionary. Pricing, sizing, legal catgories and other medicinal forms information for ifosfamide. It was reported that ifosfamide 80 mgml in sodium chloride 0. Our ifex ifosfamide side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Highlights of prescribing information given intravenously. Find patient medical information for ifosfamidemesna intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. As a single agent it has successfully produced objective remissions in a wide range of malignant conditions. Case reports of subacute interstitial pneumonias can be found in the literature, although the responsibility of ifosfamide remains unclear, as it was used in. Ifosfamide is approved to be used with other drugs to treat.
Therapeutic uses, prescribing information and product availability may vary between countries. Alternatively, mesna is given at 100% of the dose of ifosfamide and given as a continuous infusion during the ifosfamide and for 24 hours after. Dosage may be reduced, delayed or discontinued in patients with bone marrow depression due to. Ifosfamide, like cyclophosphamide, is an oxazophosphorine alkylating agent. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage ww at the time of ifosfamide administration. Mesna should be used to reduce the incidence of hemorrhagic cystitis. Ifosfamide is a synthetic structural isomer of cyclophosphamide that has been approved for concurrent use with other drugs usually cisplatin, etoposide, or vinblastine in the treatment of metastatic germcell testicular cancer and some especially pediatric sarcomas. Ifosfamide fda prescribing information, side effects and uses. Ifosfamide for injection ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. It is used in patients who have already been treated with two other types of chemotherapy ifosfamide is also being studied in the treatment of other types of cancer. The interaction of ifosfamide and aprepitant in gynecologic. Ifosfamide is a cytotoxic drug for the treatment of malignant disease. Mesnex tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide.
This is not a complete list of side effects and others may occur. Ifex ifosfamide chemotherapy, side effects navigating care. Ifosfamide medicinal forms bnf content published by nice. Jun 12, 20 ifosfamide requires activation through 4hydroxyifosfamide to ifosforamide to exert cytotoxicity. Highlights of prescribing information these highlights do not include all the information needed to use ifex safely and effectively. Ifosfamide is an alkylating agent with welldemonstrated efficacy against a large number of malignant diseases.
Fda label information for this drug is available at dailymed. The information on this website is intended for informational purposes only and is not a substitute for medical advice. The acute tubular dysfunction can be manifested by increased excretion of potassium, phosphorus, and magnesium. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Ifosfamide fda prescribing information, side effects and. Accidental release measures contain spill and collect, as appropriate. Procytox cyclophosphamide and ifex ifosfamide product monographs. Additional 20% dose reduction if toxicities recur 25 mgm2 iv over 3 hours every 3 weeks initial 20% dose reduction in the presence of toxicities 32 mgm2 iv over 3 hours every 3 weeks. Ifosfamideinduced myelosuppression can cause leukopenia, neutropenia, thrombocytopenia associated with a higher risk of bleeding events, and anemia.
Find patient medical information for ifosfamide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ifosfamide for injection should be given cautiously, if at all, to patients with presence of an infection, severe immunosuppression or compromised bone marrow reserve, as indicated by leukopenia, granulocytopenia, extensive bone marrow metastases, prior radiation therapy, or prior therapy with other cytotoxic agents. Urotoxic side effects, especially hemorrhagic cystitis, have been very commonly associated with the use of ifosfamide. Ifosfamide belongs to the group of medicines called alkylating agents. Apr 25, 2008 ifosfamide is an antineoplastic agent useful in the treatment of a wide range of cancers including sarcomas, gynecologic cancers, lymphoma and testicular cancers. You may be able to overcome this with stronger flavored herbs such as basil, sage, or thyme. Ifosfamide ifs is a new alkylating oxazaphosphorine related to cyclophosphamide. Ifosfamide is also frequently used in combination with other cytotoxic drugs, radiotherapy and surgery. Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. Aprepitant is a novel and selective antiemetic that antagonizes substance pneurokinin 1 nk1 receptors with high affinity. Pdf neurotoxicity during ifosfamide treatment in children. We report for first time acute cardiac side effects upon ifs treatment in the form of supraventricular arrhythmias and stt wave changes.
Please click here for important safety information, including boxed warning regarding hepatic impairment, and click here 2 for full prescribing information. Treatment guidelines from the medical letter drugs of choice for cancer. Ifosfamide requires activation through 4hydroxyifosfamide to ifosforamide to exert cytotoxicity. Ifosfamide information, side effects, warnings and recalls. Ifex ifosfamide dosing, indications, interactions, adverse. Please refer to mims product monographs for specific and locally approved prescribing information. Jul 01, 2019 discontinue ifosfamide or reduce dosage in patients who develop hematuria 50 erythrocyteshpf while receiving usual dosages of ifosfamide in conjunction with mesna. These highlights do not include all the information needed to use ifosfamide injection safely and effectively. Ifosfamide can also cause hypophosphatemic rickets. Following activation in the liver, ifosfamide interferes with dna through formation of phosphotriesters and dnadna crosslinks, thereby inhibiting protein synthesis and dna synthesis. The vial and vial stopper are not made with natural rubber latex. Always consult your healthcare provider if you have questions or concerns.
Ifosfamide is structurally related to cyclophosphamide and has been used in the treatment of a variety of solid tumors, including lung, testicular, and breast cancer. Ifosfamide may lower your bodys resistance and there is a chance you might get the infection the immunization is meant to prevent. Risk factors for ifosfamide nephrotoxicity include. Ifosfamide injection is used in combination with other medicines to treat cancer of the testicles ifosfamide interferes with the growth of cancer cells, which are eventually destroyed.
Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric and lung cancer. Call your doctor for medical advice about side effects. Guidelines for the administration of mesna with ifosfamide. It is used in patients who have already been treated with two other types of chemotherapy. In addition, other persons living in your house should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Tecentriq atezolizumab injection, for intravenous use initial u. Ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide.
Medlineplus information on ifosfamide a lay language summary of important information about this drug that may include the following. Ifosfamide should be administered as a slow intravenous infusion lasting a minimum of 30 minutes. Keep track of your medications including prescription drugs, overthecounter drugs, herbal supplements, and vitamins. Adequately hydrate patient prior to and during ifosfamide therapy e. Highlights of prescribing information when administering.
Studies of ifosfamide injection in patients with hepatic or renal impairment have not been conducted see use in specifi c populations 8. Myelosuppression, neurotoxicity, and urotoxicity see full prescribing information for complete boxed warning. See full prescribing information for ifosfamide injection. Ifosfamide manufacturers, ifosfamide suppliers, exporters. Ifosfamide injection 1g summary of product characteristics. See full prescribing information for complete boxed warning. Ifosfamide injection, for intravenous use initial u. Ifosfamide is also being studied in the treatment of other types of cancer. Mesna has also been given orally by doubling the iv bolus dose and giving it in the same schedule before and at 4 and 8 hours after each ifosfamide dose. Ifosfamide injection should be administered as a slow intravenous infusion lasting a minimum of 30 minutes.
Ifex ifosfamide for injection, intravenous use warning. Ifosfamide therapy is associated with minor transient serum enzyme elevations and has been linked to cases of acute. Ifosfamide interactions bnf content published by nice. Measles, mumps and rubella vaccine, live is predicted to increase the risk of generalised infection possibly lifethreatening when given with ifosfamide. See full prescribing information for recommended dosages of concomitant. Ifosfamide injection 1g summary of product characteristics smpc. These highlights do not include all the information needed.
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